LOC14

SKU: orb1220954

Description

LOC14 to be the most potent PDI inhibitor reported to date( EC50 : 500 nM).

Key Properties

• CAS Number: 877963-94-5
• MW: 317.4
• Purity: >98% (HPLC)
• Formula: C₁₆H₁₉N₃O₂S
• SMILES: O=C(C1CC1)N1CCN(Cn2sc3ccccc3c2=O)CC1
• Target: PDI
• Solubility: DMSO:25 mg/mL (78.76 mM)

Bioactivity

• In Vivo:
  Animal model: Male N171–82Q HD mice. Dosage: 20 mg/kg. Administration: Orally administered by gavage; 20 mg/kg; once daily; 12-28 weeks. Result: Improved motor function in HD mice.
• In Vitro:
  Cell Viability Assay Cell line: MTEC cells. Concentration: 0.01 μM; 0.1 μM; 0.5 μM; 1 μM; 5 μM; 10 μM; 100 μM Incubation time: 24 hours. Result: Inhibited recombinant (r)PDIA3 activity.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PDI