LNS8801

SKU: orb3028566

Description

LNS8801 is an orally active agonist of the G protein-coupled estrogen receptor (GPER). By activating GPER, LNS8801 mediates downstream signaling pathways, such as promoting cAMP production and activating CREB signaling, which results in antitumor activities like inhibiting tumor cell proliferation, inducing cell differentiation, and enhancing tumor immunogenicity. It is applicable in research across various cancers, such as melanoma, pancreatic cancer, colorectal cancer, and lung cancer, as well as studies exploring the role of GPER in normal physiological and pathological processes.

Research Area

Metabolism Research

Key Properties

• CAS Number: 925419-55-2
• MW: 412.277
• Formula: C₂₁H₁₈BrNO₃
• SMILES: BrC1=C([C@@H]2[C@]3([C@@](C=4C(N2)=CC=C(C(C)=O)C4)(C=CC3)[H])[H])C=C5C(=C1)OCO5
• Target: Estrogen Receptor/ERR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Estrogen Receptor/ERR