LMTK3-IN-1

SKU: orb1944755

Description

LMTK3-IN-1 is a potent, ATP-competitive inhibitor of Lemur Tyrosine Kinase 3 (Kd=2.5 µM) that induces its degradation via the ubiquitin-proteasome pathway. It demonstrates pro-apoptotic and anticancer activity in breast cancer cell lines (10-20 µM) and has shown efficacy in preclinical in vivo models of breast cancer.

Research Area

Signal Transduction

Key Properties

• CAS Number: 2764850-23-7
• MW: 356.3
• Purity: 99.58% (May vary between batches)
• Formula: C₁₈H₁₁F₃N₄O
• SMILES: FC(F)(F)OC1=CC=CC(=C1)C2=CN=C3C=CC(=NN32)C=4C=CN=CC4
• Target: c-Met/HGFR
• Solubility: DMSO:9.17 mg/mL (25.74 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LMTK3IN1, LMTK3-IN-1, HGFR, cMet, c-Met/HGFR, c-Met, cMet/HGFR

Compound Identifiers

PubChem CID

138454301