LMPTP INHIBITOR 1 hydrochloride

SKU: orb1302817

Description

LMPTP INHIBITOR 1 hydrochloride is a potent and selective low molecular weight protein tyrosine phosphatase (LMPTP-A) inhibitor, exhibiting an IC₅₀ of 0.8 µM. This compound is a valuable research tool for investigating LMPTP's role in metabolic diseases, such as insulin resistance and diabetes, in both cellular and animal models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2310135-38-5
• MW: 481.07
• Purity: 99.89% (May vary between batches)
• Formula: C₂₈H₃₇ClN₄O
• SMILES: CCN(C(c1ccc(c(cc2NCCCN3CCCCC3)nc4c2cccc4)cc1)=O)CC.Cl
• Target: Phosphatase
• Solubility: DMSO:9 mg/mL (18.71 mM)

Bioactivity

• Target IC50:
  LMPTPA:0.8 μM
• In Vivo:
  LMPTP inhibitor 1, an orally bioavailable compound, achieves approximately 680 nM mean serum concentration at 0.03% w/w dosage and surpasses 3 μM at 0.05% w/w dosage, effectively reversing diabetes in obese mice. At 0.05% w/w, it inhibits LMPTP activity, markedly enhances glucose tolerance, and lowers fasting insulin levels in diabetic DIO mice without impacting body weight .
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• In Vitro:
  LMPTP INHIBITOR 1 (hydrochloride) is a selective inhibitor of low molecular weight protein tyrosine phosphatase, with an IC 50 of 0.8 μM for LMPTP-A. LMPTP INHIBITOR 1 shows more potent effect on LMPTP-A versus LMPTP-B. LMPTP inhibitor 1 (Compound 23; 10 μM) also enhances HepG2 IR phosphorylation after insulin stimulation in human HepG2 hepatocytes .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LMPTP INHIBITOR 1 Hydrochloride, LMPTP INHIBITOR 1 hydrochloride, LMPTP INHIBITOR 1 hydrochloride (1908414-82-3(free base)), LMPTP-A

Compound Identifiers

PubChem CID

134691743