LMPTP INHIBITOR 1 dihydrochloride

SKU: orb1303123

Description

LMPTP Inhibitor 1 Dihydrochloride is a selective, potent inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP-A), with an IC50 of 0.8 µM. This compound is a valuable research tool for investigating LMPTP's role in metabolic diseases and insulin signaling pathways in both cellular and animal models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2310135-46-5
• MW: 517.53
• Purity: 99.83% (May vary between batches)
• Formula: C₂₈H₃₈Cl₂N₄O
• SMILES: Cl.Cl.CCN(CC)C(=O)c1ccc(cc1)-c1cc(NCCCN2CCCCC2)c2ccccc2n1
• Target: Phosphatase
• Solubility: DMSO:64 mg/mL (123.66 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.86 mM);H2O:50 mg/mL (96.61 mM)

Bioactivity

• Target IC50:
  LMPTPA:0.8 μM
• In Vivo:
  LMPTP inhibitor 1 dihydrochloride, an orally bioavailable compound, achieves an approximate mean serum concentration of 680 nM following 0.03% w/w administration and exceeds 3 μM with 0.05% w/w dosage. Notably, it reverses diabetes in obese mice. At a concentration of 0.05% w/w, it effectively inhibits LMPTP activity, leading to a significant enhancement in glucose tolerance and a reduction in fasting insulin levels in diabetic DIO mice, with no impact on body weight.
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• In Vitro:
  LMPTP INHIBITOR 1 dihydrochloride is a selective inhibitor of low molecular weight protein tyrosine phosphatase, with an IC50 of 0.8 μM LMPTP-A and shows more potent effect on LMPTP-A versus LMPTP-B. LMPTP inhibitor 1 dihydrochloride (10 μM) also enhances HepG2 IR phosphorylation after insulin stimulation in human HepG2 hepatocytes.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LMPTP inhibitor1, LMPTP inhibitor-1, LMPTP inhibitor 1, LMPTP INHIBITOR 1, LMPTP INHIBITOR 1 dihydrochloride, LMPTP INHIBITOR 1 Dihydrochloride, inhibit, Inhibitor, protein tyrosine phosphatase(PTP), Phosphatase

Compound Identifiers

PubChem CID

134691744