LML134

SKU: orb1298866

Description

LML134 (LML-134) is a potent and selective inverse agonist of the human Histamine H3 Receptor (H3R), demonstrating high affinity with Kis of 0.3 nM in cAMP assays and 12 nM in binding assays. This small molecule is a valuable research tool for investigating H3R function in neurological disorders, supporting both in vitro mechanistic studies and in vivo preclinical research.

Research Area

Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1542135-76-1
• MW: 375.47
• Purity: 99.86% (May vary between batches)
• Formula: C₁₉H₂₉N₅O₃
• SMILES: Cn1nc(ccc1=O)N1CCC(CC1)OC(=O)N1CCN(CC1)C1CCC1
• Target: Histamine Receptor
• Solubility: DMSO:7.5 mg/mL (19.97 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.66 mM)

Bioactivity

• Target IC50:
  H3 receptor cAMP (human):0.3 nM(ki) |H3 receptor bdg (human):12 nM (ki)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

H3 receptor, Histamine Receptor, HistamineReceptor, Inhibitor, LML 134, LML134, LML-134, inhibit

Compound Identifiers

PubChem CID

72948400