LM22A-4

SKU: orb1299701

Description

LM22A-4

Research Area

Signal Transduction

Key Properties

• CAS Number: 37988-18-4
• MW: 339.34
• Purity: 99.56%
• Formula: C₁₅H₂₁N₃O₆
• SMILES: OCCNC(=O)c1cc(cc(c1)C(=O)NCCO)C(=O)NCCO
• Target: Trk receptor
• Solubility: DMSO:45 mg/mL (132.61 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.89 mM);H2O:50 mg/mL (147.34 mM)

Bioactivity

• Target IC50:
  TrkB:47 nM
• In Vivo:
  Treatment of Het mice with LM22A-4 for 4 weeks rescued wild-type levels of TrkB phosphorylation in the medulla and pons and restored wild-type breathing frequenc.
• In Vitro:
  In vitro, LM22A-4 increases survival of hippocampal neurons via activation of TrkB as well as Akt and ERK downstream pro-survival signaling pathway.
• Animal Research:
  Wt and Het littermates were divided into 4 groups: Wt Vehicle-treated (100 μL of 0.9% NaCl, i.p., b.i.d.), Wt drug-treated (50 mg/kg LM22A-4 in 0.9% NaCl, i.p., b.i.d.), Het Vehicle-treated (100 μL of 0.9% NaCl, i.p., b.i.d.), and Het drug-treated (50 mg/kg LM22A-4 in 0.9% NaCl, i.p., b.i.d.). Each mouse was treated from 8 to 13 weeks of age.?Whole-body plethysmography was performed during week 12 and animals were Subsequently killed and tissues Harvested for TrkB Western blots and BDNF ELISA during wee.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

inhibit, LM22A 4, LM22A4, LM-22A-4, LM22A-4, Inhibitor, Trk, Trk Receptor, Trk receptor, Tropomyosin related kinase receptor, Trkreceptor

Compound Identifiers

PubChem CID

2054170