LM22A-4

SKU: orb1299701

Description

LM22A-4 is a small molecule agonist of the TrkB receptor, mimicking the neurotrophic effects of BDNF with an IC50 of 47 nM. It is utilized in neuroscience research to study neuroprotection, synaptic plasticity, and neuronal survival in both cellular and animal models of neurological disorders.

Research Area

Signal Transduction

Key Properties

• CAS Number: 37988-18-4
• MW: 339.34
• Purity: 99.56% (May vary between batches)
• Formula: C₁₅H₂₁N₃O₆
• SMILES: OCCNC(=O)c1cc(cc(c1)C(=O)NCCO)C(=O)NCCO
• Target: Trk receptor
• Solubility: DMSO:45 mg/mL (132.61 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.89 mM);H2O:50 mg/mL (147.34 mM)

Bioactivity

• Target IC50:
  TrkB:47 nM
• In Vivo:
  Treatment of Het mice with LM22A-4 for 4 weeks rescued wild-type levels of TrkB phosphorylation in the medulla and pons and restored wild-type breathing frequency.
• In Vitro:
  In vitro, LM22A-4 increases survival of hippocampal neurons via activation of TrkB as well as Akt and ERK downstream pro-survival signaling pathways.
• Animal Research:
  Wt and Het littermates were divided into 4 groups: Wt vehicle-treated (100 μl of 0.9% NaCl, i.p., b.i.d.), Wt drug-treated (50 mg/kg LM22A-4 in 0.9% NaCl, i.p., b.i.d.), Het vehicle-treated (100 μl of 0.9% NaCl, i.p., b.i.d.), and Het drug-treated (50 mg/kg LM22A-4 in 0.9% NaCl, i.p., b.i.d.). Each mouse was treated from 8 to 13 weeks of age. Whole-body plethysmography was performed during week 12 and animals were subsequently killed and tissues harvested for TrkB Western blots and BDNF ELISA during week.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, LM22A 4, LM22A4, LM-22A-4, LM22A-4, Inhibitor, Trk, Trk Receptor, Trk receptor, Tropomyosin related kinase receptor, Trkreceptor

Compound Identifiers

PubChem CID

2054170