LM11A-31

SKU: orb1309474

Description

LM11A-31 dihydrochloride is a water-soluble, brain-penetrant small molecule that acts as a p75NTR ligand and proNGF antagonist. It is utilized in research on neurodegenerative diseases, with studies demonstrating its neuroprotective effects in both in vitro models and in vivo animal studies of Alzheimer's disease and spinal cord injury.

Research Area

Neuroscience, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1243259-19-9
• MW: 316.27
• Purity: >98%
• Formula: C₁₂H₂₅N₃O₂ 2HCl
• SMILES: Cl.Cl.CC[C@H](C)[C@H](N)C(=O)NCCN1CCOCC1
• Target: Neurotensin Receptor,Others
• Solubility: Soluble in DMSO (up to 20 mg/ml) or in Water (up to 30 mg/ml).

Bioactivity

• In Vivo:
  LM11A-31 (orally; 50 or 75 mg/kg) administered for 3 months starting at 6-8 months of age prevents and/or reverses atrophy of basal forebrain cholinergic neurites and cortical dystrophic neurites in mid-stage male APPL/S mice. LM11A-31 (oral gavage; 50 mg kg/day for 4 weeks) significantly mitigates proNGF accumulation and preserves BRB integrity.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cholinergic, disease, dystrophy, Alzheimer's, blood-brain, barrier, growth, factor, neurite, Neurotensin Receptor, neurotrophin, nerve, Inhibitor, Ligand, p75, p75NTR, LM11A 31 dihydrochloride, LM11A-31, LM11A31 dihydrochloride, LM-11A-31 dihydrochloride, LM11A-31 Dihydrochloride, inhibit, proNGF, receptor

Compound Identifiers

PubChem CID

91654620