LM11A-31 dihydrochloride

SKU: orb1309474

Description

LM11A-31 dihydrochloride is a water-soluble, brain-penetrant small molecule that acts as a p75NTR ligand and proNGF antagonist. It is utilized in research on neurodegenerative diseases, with studies demonstrating its neuroprotective effects in both in vitro models and in vivo animal studies of Alzheimer's disease and spinal cord injury.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1243259-19-9
• MW: 316.27
• Purity: 98.00%
• Formula: C₁₂H₂₇Cl₂N₃O₂
• SMILES: Cl.Cl.CC[C@H](C)[C@H](N)C(=O)NCCN1CCOCC1
• Target: Neurotensin Receptor,Others
• Solubility: H2O:125 mg/mL (395.23 mM)

Bioactivity

• In Vivo:
  LM11A-31 (orally; 50 or 75 mg/kg) administered for 3 months starting at 6-8 months of age prevents and/or reverses atrophy of basal forebrain cholinergic neurites and cortical dystrophic neurites in mid-stage male APPL/S mice. LM11A-31 (oral gavage; 50 mg kg/day for 4 weeks) significantly mitigates proNGF accumulation and preserves BRB integrity.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cholinergic, disease, dystrophy, Alzheimer's, blood-brain, barrier, growth, factor, neurite, Neurotensin Receptor, neurotrophin, nerve, Inhibitor, Ligand, p75, p75NTR, LM11A 31 dihydrochloride, LM11A-31, LM11A31 dihydrochloride, LM-11A-31 dihydrochloride, LM11A-31 Dihydrochloride, inhibit, proNGF, receptor

Compound Identifiers

PubChem CID

91654620