LLY-507

SKU: orb1225903

Description

A potent, selective and cell-active inhibitor of SMYD2 (IC50100-fold selective over a broad range of methyltransferase and non-methyltransferase targets; inhibits SMYD2-mediated methylation of p53 Lys370 and suppresses proliferation of several esophageal, liver, and breast cancer cell lines in a dose-dependent manner (IC50=1.5-6 uM).

Key Properties

• CAS Number: 1793053-37-8
• MW: 574.7583
• Purity: >98% (HPLC)
• Formula: C₃₆H₄₂N₆O
• SMILES: O=C(C1=CC(C2=CC=CC=C2N3CCN(CCN4C=C(C)C5=C4C=CC=C5)CC3)=CC(C#N)=C1)NCCCN6CCCC6
• Target: HMTase
• Solubility: DMSO: 15 mg/mL

Bioactivity

• In Vitro:
  Cell Proliferation Assay Cell line: ESCC, HCC, breast cancer cell lines. Concentration: 0-20 μM. Incubation time: 3 days, 7 days. Result: Inhibited tumor cell proliferation. Western blot analysis. Cell line: HEK293 cells. Concentration: 0.03 μM, 0.07 μM, 0.15 μM, 0.3 μM, 0.6 μM, 1.25 μM, 2.5 μM Incubation time: 28 hours. Result: Inhibited SMYD2-mediated methylation of p53 Lys370 in cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LLY-507 | LLY 507 | LLY507

Quick Database Links

Gene Symbol

HMTase