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LL-K8-22

SKU: orb1982623

Description

LL-K8-22 is a potent, selective, and durable dual degrader of CDK8-cyclin C, demonstrating DC50 values of 2.52 and 2.64 μM, respectively. This compound effectively suppresses STAT1 Ser 727 phosphorylation and inhibits carcinogenic transcriptional programs driven by E2F and MYC. LL-K8-22 is specifically utilized in research for triple-negative breast cancer (TNBC).

Images & Validation

Key Properties

MW573.77
FormulaC37H43N5O
TargetOthers,STAT,CDK,Early 2 Factor (E2F)

Storage & Handling

Storage-20°C
DisclaimerFor research use only

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LL-K8-22 (orb1982623)

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