LJ-001

SKU: orb1696427

Description

LJ-001 is a broad-spectrum antiviral small molecule active against numerous enveloped viruses, including transmissible gastroenteritis virus (TGEV) and porcine delta coronavirus (PDCoV). It is a valuable research tool for studying viral entry mechanisms in both in vitro and in vivo infection models.

Research Area

Immunology & Inflammation, Infectious Disease & Virology, Protein Biochemistry

Key Properties

• CAS Number: 851305-26-5
• MW: 327.42
• Purity: 98.02%
• Formula: C₁₇H₁₃NO₂S₂
• SMILES: C(\C=1OC(=CC1)C2=CC=CC=C2)=C\3/C(=O)N(CC=C)C(=S)S3
• Target: HIV Protease,HCV Protease,Antiviral
• Solubility: DMSO:3.28 mg/mL (10.02 mM)

Bioactivity

• In Vivo:
  In female BALB/c mice, oral gavage and intraperitoneal administration of LJ001 (20-50 mg/kg) shows no toxicity except a slight elevation in serum cholesterol levels.
• In Vitro:
  In ST cells, LJ001 (12.5 µM) decreases the N-protein expression of TGEV and PDCoV and the gene mRNA expression in a time-dependent manner. LJ001 shows activities against HIV, HCV, influenza, Ebola, poxviruses and arenaviruses.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DNA viruses, HCV, HIVProtease, HIV Protease, HIV, LJ001, LJ-001, LJ 001, RNA viruses

Compound Identifiers

PubChem CID

2272467