Litorin acetate(55749-97-8 Free base)

SKU: orb1306597

Description

Litorin acetate is a bombesin receptor agonist derived from amphibian peptides. It is used in research to study smooth muscle contraction, gastrointestinal hormone secretion (e.g., gastrin), and nutrient metabolism suppression in vivo, with applications in physiology and pharmacology.

Research Area

Pharmacology & Drug Discovery

Key Properties

• MW: 1145.29
• Purity: 97.64% (May vary between batches)
• Formula: C₅₃H₇₂N₁₄O₁₃S
• SMILES: CC(O)=O.CSCC[C@@H](C(N)=O)NC([C@H](CC1=CC=CC=C1)NC([C@H](CC2=CNC=N2)NC(CNC([C@H](C(C)C)NC([C@H](C)NC([C@H](CC3=CNC4=C3C=CC=C4)NC([C@H](CCC(N)=O)NC([C@H](CC5)NC5=O)=O)=O)=O)=O)=O)=O)=O)=O
• Target: Bombesin Receptor
• Solubility: DMSO:110.09 mg/mL (96.12 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vivo:
  Litorin stimulates the contraction of smooth muscle, stimulates gastrin, gastric acid, and pancreatic secretion, and suppresses the nutriment in in vivo experiments.
• In Vitro:
  99mTc-Litorin is developed for non-invasive imaging of tumors with overexpressed gastrin-releasing peptide receptors (GRP-R). [D-Phe1,Leu8,9]Litorin inhibits binding of 125I-[Tyr4] BN to murine Swiss 3T3 cells with a Ki of 5.1 nM. Litorin stimulates 3H-Thymidine incorporation in murine Swiss 3T3 cells with an EC50 of 2.3 nM.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bombesin Receptor, BombesinReceptor, Litorin acetate, Litorin acetate(55749-97-8 Free base)

Compound Identifiers

PubChem CID

168012318