LIT-927

SKU: orb1225651

Description

LIT-927 (LIT927) is the first selective, locally and orally active CXCL12 neutraligand with Ki of 267 nM for CXCL12-TR binding inhibition; displays excellent selectivity over other chemokines (CCL17, CCL22, CCL5 and CCL2), inhibits the increase in intracellular calcium concentration in EGFP-CXCR4+HEK cells in response to CXCL12 at 10 uM, has no effect on calcium responses triggered by either CCL17 or CCL22 on EGFP-CCR4+HEK cells, CCL5 on EGFP-CCR5+ HEK cells, or by CCL2 on EGFP-CCR2+HEK cells; reduces eosinophil recruitment in murine model of allergic airway hypereosinophilia.

Key Properties

• CAS Number: 2172879-52-4
• MW: 328.752
• Purity: >98% (HPLC)
• Formula: C₁₇H₁₃ClN₂O₃
• SMILES: O=C1N=C(C2=CC=C(Cl)C=C2)C=C(C3=CC=C(O)C(OC)=C3)N1
• Target: Chemokine Receptor
• Solubility: DMSO: 25 mg/mL, 76.05 mM; Water: Insoluble （ < 1 mg/ml refers to the product slightly soluble or insoluble )

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LIT927

Quick Database Links

Gene Symbol

Chemokine Receptor