Lisaftoclax

SKU: orb1710305

Description

Lisaftoclax is an orally bioavailable small molecule that potently inhibits the anti-apoptotic proteins Bcl-2 (IC50=2 nM) and Bcl-xL (IC50=5.9 nM). It is used in research for chronic lymphocytic leukemia (CLL), demonstrating pro-apoptotic activity in both cellular assays and in vivo models.

Research Area

Cell Biology

Key Properties

• CAS Number: 2180923-05-9
• MW: 882.42
• Purity: 99.66% (May vary between batches)
• Formula: C₄₅H₄₈ClN₇O₈S
• SMILES: [O-][N+](=O)c1cc(ccc1NC[C@H]1COCCO1)S(=O)(=O)NC(=O)c1ccc(cc1Oc1cnc2[nH]ccc2c1)N1CCN(CC2=C(CC3(CCC3)CC2)c2ccc(Cl)cc2)CC1
• Target: Bcl-2 Family
• Solubility: DMSO:45 mg/mL (51 mM)

Bioactivity

• Target IC50:
  Bcl-2:2 nM|BCL-XL:5.9 nM
• In Vitro:
  Lisaftoclax shows IC50s of 5.5 nM and 6.4 nM in Bcl-2 dependent RS4 11 cells and Bcl-xl dependent Molm 13 cells.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Lisaftoclax, APG2575, APG-2575, APG 2575, Bcl-xL, Bcl-2, Bcl-2/Bcl-xl inhibitor 1

Compound Identifiers

PubChem CID

137355972