Liriodenine

SKU: orb1684452

Description

Liriodenine

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Protein Biochemistry

Key Properties

• CAS Number: 475-75-2
• MW: 275.26
• Purity: 97.00% (May vary between batches)
• Formula: C₁₇H₉NO₃
• SMILES: O=C1C2=NC=CC3=CC=4OCOC4C(C=5C=CC=CC15)=C32
• Target: Antifungal,Antiviral,Apoptosis,Caspase,Antibacterial

Bioactivity

• Target IC50:
  MLKL (HT-29 cells):11.02 μM|HT29 cells:11.02 μM|KB cells:9.60 μM|A549 cells:9.20 μM|HEK293 cells:8.07μM
• In Vivo:
  Methods: Liriodenine (0.01, 0.1 mg/kg, intravenous) was administered to rats to determine whether the effective antiarrhythmic dose of 0.01 mg/kg liriodenine has an effect on left ventricular (LV)-arterial coupling in Wistar rats. Results: Liriodenine at a dose of 0.01 mg/kg did not cause significant changes in basal heart rate (HR), cardiac output (CO), LV end-systolic pressure (Pes), Ea, Ees, and Q load, whereas liriodenine at a dose of 0.1 mg/kg caused a significant decrease in HR by 2.0%, a significant increase in CO by 5.8%, but no significant change in Pes. In addition, administration of 0.1 mg/kg liriodenine to rats significantly decreased Ees by 8.5% and Ea by 10.6%, but did not change Q load.
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• In Vitro:
  Methods: Liriodenine (0.16-20 μg/mL, 48 hours) was used to treat human oral epidermoid carcinoma (KB), human colon cancer (Col-2 and HT-29), human breast cancer (MCF-7), human lung cancer (Lu-1 and A549), rat glioma (ASK), and noncancerous human embryonic kidney cells (HEK-293), and cytotoxicity was determined using the sulforhodamine B assay. Results: Liriodenine showed IC50 values ​​of 9.60 μM, 11.02 μM, 10.62 μM, 9.20 μM and 8.07 μM for KB, HT-29, MCF-7, A549, ASK, and HEK-293 cells, respectively.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bcl-2, Caspase, p53, Liriodenine, Spermatheridine, VLT045

Compound Identifiers

PubChem CID

10144