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Liproxstatin-1

SKU: orb1223543

Description

Liproxstatin-1 is a specific small molecule ferroptosis inhibitor (IC50=22 nM) via inactivation of the ferroptosis regulator Gpx4 (glutathione peroxidase 4), shows no activity on necroptosis; prevents BODIPY 581/591 C11 oxidation in Gpx4 / cells, does not interfere with other classical types of cell death, such as TNFα-induced apoptosis and H2O2-induced necrosis; suppresses ferroptosis in Gpx4(-/-) mice, and in a pre-clinical model of ischaemia/reperfusion-induced hepatic damage.

Images & Validation

Key Properties

CAS Number950455-15-9
MW340.8499
Purity>98% (HPLC)
FormulaC19H21ClN4
SMILESClC1=CC(CNC(C23CCNCC2)=NC4=C(N3)C=CC=C4)=CC=C1
TargetFerroptosis
SolubilityDMSO: ≥ 31 mg/mL

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Liproxstatin 1

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Protocol Information

Liproxstatin-1 (orb1223543)

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200 mg
500 mg
2 mg
$ 90.00
5 mg
$ 140.00
10 mg
$ 210.00
25 mg
$ 430.00
50 mg
$ 670.00
100 mg
$ 730.00