Liproxstatin-1

SKU: orb1223543

Description

Liproxstatin-1 is a specific small molecule ferroptosis inhibitor (IC50=22 nM) via inactivation of the ferroptosis regulator Gpx4 (glutathione peroxidase 4), shows no activity on necroptosis; prevents BODIPY 581/591 C11 oxidation in Gpx4 / cells, does not interfere with other classical types of cell death, such as TNFα-induced apoptosis and H2O2-induced necrosis; suppresses ferroptosis in Gpx4(-/-) mice, and in a pre-clinical model of ischaemia/reperfusion-induced hepatic damage.

Key Properties

• CAS Number: 950455-15-9
• MW: 340.8499
• Purity: >98% (HPLC)
• Formula: C₁₉H₂₁ClN₄
• SMILES: ClC1=CC(CNC(C23CCNCC2)=NC4=C(N3)C=CC=C4)=CC=C1
• Target: Ferroptosis
• Solubility: DMSO: ≥ 31 mg/mL

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Liproxstatin 1

Quick Database Links

Gene Symbol

Ferroptosis