Lipoxamycin hemisulfate

SKU: orb1701496

Description

Lipoxamycin hemisulfate is a potent serine palmitoyltransferase inhibitor (IC50 = 21 nM). This antifungal agent is a valuable research tool for studying sphingolipid biosynthesis in vitro and exploring antifungal mechanisms.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 11075-87-9
• MW: 843.08
• Purity: 99.06% (May vary between batches)
• Formula: C₃₈H₇₄N₄O₁₄S
• SMILES: CC(C)CCCC(=O)CCCCCCC(=O)CCN(C(=O)[C@H](CO)N)O.CC(C)CCCC(=O)CCCCCCC(=O)CCN(C(=O)[C@H](CO)N)O.OS(=O)(=O)O
• Target: Antibiotic,Antifungal
• Solubility: DMSO:36 mg/mL (42.7 mM);10% DMSO+90% Saline:3.3 mg/mL (3.91 mM)

Bioactivity

• In Vivo:
  In Chinese hamster ovary cell mutant, Lipoxamycin hemisulfate is highly toxic in mice when applied subeutaneously or topically.
• In Vitro:
  Lipoxamycin hemisulfate shows antifungal activity against a panel of human pathogenic fungi with better potency against some of the Candida species (MIC = 0.25-16 µg/mL).

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Fungal, Lipoxamycin, Lipoxamycin Hemisulfate, Lipoxamycin, Sulfate, Lipoxamycin, sulfate (2:1), 2:1, U 26146D, U26146D, U-26146D

Compound Identifiers

PubChem CID

165905