Lipopolysaccharides, from E. coli O26:B6

SKU: orb2941217

Description

Lipopolysaccharides from *E. coli* (Escherichia coli) O26:B6 are endotoxins derived from *E. coli* that function as TLR-4 activators. These S-type LPS molecules can trigger pathogenic-associated molecular patterns (PAMP) and encourage the release of exosomes. Structurally, they are composed of three parts: O-antigen, core oligosaccharide, and Lipid A, and can be identified by the monoclonal antibody MAb J8-4C10. This compound can increase pro-inflammatory cytokines in plasma, leading to activation of the hypothalamic-pituitary-adrenal (HPA) axis and causing oxidative damage to the adrenal glands. However, the pathogenic activity of Lipopolysaccharides from *E. coli* O26:B6 can be inhibited by PD149163 .

Research Area

Infectious Disease & Virology

Key Properties

• Target: TLR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

TLR