Lipid TG4C

SKU: orb3026229

Description

Lipid TG4C, an ionizable cationic glycerolipid (pKa = 6.71), has been utilized for creating lipid nanoparticles (LNPs) designed to deliver mRNA in vivo. In mice, these LNPs containing lipid TG4C and mRNA encoding human erythropoietin (EPO) result in increased serum EPO levels. Additionally, inhalation of LNPs with lipid TG4C carrying mRNA for human hepatocyte growth factor (HGF) decreases levels of Il-1β, Il-6, and Tnf-α in bronchoalveolar lavage fluid (BALF) in a mouse model of pulmonary emphysema induced by porcine pancreatic elastase.

Research Area

Metabolism Research

Key Properties

• CAS Number: 3028336-07-1
• MW: 938.41
• Formula: C₅₅H₁₀₃NO₁₀
• SMILES: O=C(OCC(OC(=O)CCCN(C)C)COC(=O)CCCCC(=O)OC(CCCCCCCC)CCCCCCCC)CCCCC(=O)OC(CCCCCCCC)CCCCCCCC
• Target: Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Others