Lipid C16-C

SKU: orb3178015

Description

Lipid C16-C is an ionizable cationic lipid utilized in creating lipid nanoparticles (LNPs) for mRNA delivery both in vitro and in vivo. LNPs with lipid C16-C are preferentially directed to the liver and spleen in mice over other organs such as the lungs, kidneys, lymph nodes, and heart. These LNPs, when encapsulating mRNA for HER2-targeting chimeric antigen receptor (CAR), prompt CAR expression in human macrophages ex vivo and have shown to induce cytotoxic effects in HER2-expressing SKOV3 ovarian cancer cells in vitro.

Key Properties

• Target: Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Others