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Lipid 114

SKU: orb3137724

Description

Lipid 114 is an ionizable cationic lipid with a pKa of approximately 6.8. It is utilized to create lipid nanoparticles (LNPs) for delivering siRNA both in vivo and in vitro. Lipid 114 LNPs encapsulating siRNA targeting IL-1β can reduce IL-1β expression in macrophages. Additionally, these LNPs lower IL-1β expression in the liver and kidneys and alleviate liver inflammation in a mouse model of LPS-induced acute liver failure.

Research Area

Metabolism Research

Images & Validation

Key Properties

TargetLiposome

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information