Liothyronine

SKU: orb1307879

Description

Liothyronine

Research Area

Metabolism Research

Key Properties

• CAS Number: 6893-02-3
• MW: 650.97
• Purity: 99.33%
• Formula: C₁₅H₁₂I₃NO₄
• SMILES: N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(O)=O
• Target: Thyroid hormone receptor(THR),Endogenous Metabolite
• Solubility: DMSO:3.25 mg/mL (4.99 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4.95 mg/mL (7.6 mM)

Bioactivity

• Target IC50:
  TRα:2.33 nM (Ki)|THRβ:2.29 nM (Ki)|HeLa cells:2.4 nM (EC50)
• In Vivo:
  METHODS: To detect anti-tumor activity in vivo Liothyronine (1.5-5 mg/kg, normal saline with 3% DMSO and 0.5% Tween-80) was injected intraperitoneally every two days for two weeks into C57B-/- mice bearing MC38 tumors. Results: Both low and high doses of Liothyronine significantly inhibite the growth of MC38 tumors. Liothyronine significantly increase the frequency of tumor-infiltrating CD8+ T cells and significantly enhance the secretion of IFN-γ by tumor-infiltrating CD4+ T cells treated with high doses of Liothyronine.
• In Vitro:
  METHODS: Mouse colon adenocarcinoma cells MC38 were treated with Liothyronine (12.5-100 µM) for 24-72 h. Cell viability was measured using MTT Assay. Results: Liothyronine did not affec the cell viability of MC38 cells a the concentration tested. METHODS: Jurkat hTIGIT cells were stimulated with anti-CD3 and anti-CD28 stimulatory antibodies and treated with anti-TIGIT (1 µg/mL) and Liothyronine (100 µM) for 48 h the frequency of IL-2 secreting Jurkat hTIGIT was detected using Flow cytometry. Results: TIGIT/PVR interaction significantly inhibited IL-2 secretion from Jurkat hTIGIT cells, an the Inhibition was significantly reversed by a functional anti-TIGIT antibody and Liothyronine, which ha the typical characteristics of an immune checkpoint blocker.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

EndogenousMetabolite, Endogenous Metabolite, L-3,3',5-Triiodothyronine, Lyothyronine, 3,3',5-Triiodo-L-thyronine, TRα, TRβ, Tresitope, Triiodothyronine, T3, T-3, T 3, Thyroid hormone receptor(THR), Thyroidhormonereceptor, Thyroidhormonereceptor(THR), Thyroid hormone receptor, thyroid hormone, THR

Compound Identifiers

PubChem CID

5920