Linsidomine hydrochloride

SKU: orb1704064

Description

Linsidomine hydrochloride

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 16142-27-1
• MW: 206.63
• Purity: 99.81%
• Formula: C₆H₁₁ClN₄O₂
• SMILES: Cl.NC1=CN(NO1)N1CCOCC1
• Target: Autophagy,Annexin A,ROS,NF-κB,Apoptosis,Drug Metabolite
• Solubility: H2O:45 mg/mL (217.78 mM);DMSO:22.5 mg/mL (108.89 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:2 mg/mL (9.68 mM)

Bioactivity

• In Vivo:
  SIN-1 (chloride) is the active metabolite of molsidomine. SIN-1 (chloride) exhibits a potent vasorelaxant effect and inhibition of platelet aggregation. SIN-1 (chloride) decreases myocardial necrosis and reperfusion-induced endothelial dysfunction in models of myocardial ischemia-reperfusion.
• In Vitro:
  SIN-1 decreases myocardial necrosis and reperfusion-induced endothelial dysfunction in models of myocardial ischemia-reperfusion .

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DrugMetabolite, Drug Metabolite, Linsidomine Hydrochloride, SIN1 Chloride, SIN-1 Chloride, SIN-1 chloride, SIN 1 Chloride

Compound Identifiers

PubChem CID

139592739