γ-Linolenic Acid methyl ester

SKU: orb1218683

Description

γ-Linolenic Acid methyl ester is a weak leukotriene B4 (LTB4) receptor antagonist.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 16326-32-2
• MW: 292.46
• Purity: >98% (HPLC)
• Formula: C₁₉H₃₂O₂
• SMILES: CCCCC/C=C\C/C=C\C/C=C\CCCCC(OC)=O
• Target: LTR
• Solubility: DMSO: 100mg/ml (341.88 mM); dimethyl formamide: 100mg/ml (341.88 mM)

Bioactivity

• In Vivo:
  γ-Linolenic Acid methyl ester decreases the hepatic triglycerides and histological evidence of fatty liver induced by EtOH. γ-Linolenic Acid methyl ester could significantly decrease levels of plasma total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C), MDA, atherosclerosis index (AI) and liver TC, MDA, and increase levels of high density lipoprotein cholesterol (HDL-C) in both normal and hyperlipidemic rats. Animal model: Hepatic pathol rats model induced by EtOH (male Sprague-Dawley rats, 250-300 g). Dosage: 90 mL, 50-60 mL. Administration: Intraperitoneal injection; once daily; administrated 90 mL during day 1-5 and day 9, 50-60 mL during day 6-8. Result: Decreased the hepatic triglycerides of 25.6 mg/g compared with saline (40.2 mg/g) or olive oil (42.8 mg/g) treatment. Decreased liver index (the ratio of liver weight and body wight) in hyperlipidemic rats, but had no significant effect in normal rats.
• In Vitro:
  γ-Linolenic Acid methyl ester (1-4 μg/mL; 72 h) induces apoptosis in vitro A-549 lung cancer cell lines using SRB assay. However GLA is due to its action at the gene/oncogene level and by altering BCl-2 expression Apoptosis Analysis Cell line: A-549 lung cancer cell line. Concentration: 1, 2, 3, and 4 μg/mL. Incubation time: 72 hours; observed at 24 h, 48 h, and 72 h. Result: Showed cytotoxicity potentially due to the induction of apoptosis of tumor cells by augmenting free radical generation only in the tumor cells but not normal cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Methyl gamma-linolenate

Quick Database Links

Gene Symbol

LTR