Lifitegrast sodium

SKU: orb1691063

Description

Lifitegrast sodium is a small molecule integrin antagonist that blocks the LFA-1/ICAM-1 interaction, thereby inhibiting T-cell mediated inflammation on the ocular surface. It is widely used in dry eye disease research, with applications in both in vitro binding assays and in vivo preclinical models of ocular inflammation.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 1119276-80-0
• MW: 637.46
• Purity: 99.33% (May vary between batches)
• Formula: C₂₉H₂₃Cl₂N₂NaO₇S
• SMILES: ClC1=C2C(CN(CC2)C(C3=CC=C(C=CO4)C4=C3)=O)=CC(Cl)=C1C(N[C@H](C([O-])=O)CC5=CC(S(C)(=O)=O)=CC=C5)=O.[Na+]
• Target: Integrin
• Solubility: DMSO:80 mg/mL (125.5 mM);H2O:80 mg/mL (125.5 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (5.18 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

integrin, Lifitegrast sodium, SAR 1118-023, SAR 1118-023 sodium, SAR-1118-023, SAR1118-023, SAR-1118-023 sodium, SAR1118-023 sodium, SHP-606 sodium, Xiidra, Xiidra sodium

Compound Identifiers

PubChem CID

56963348