Lifirafenib maleate

SKU: orb2565874

Description

Lifirafenib maleate (BGB-283) is a novel dual-target inhibitor of BRaf V600E and EGFR, demonstrating potent in vitro activity with IC50 values of 23 nM and 29 nM, respectively. It has been utilized in preclinical research to study targeted therapies in cancers driven by these kinases, including in vivo models of colorectal and non-small cell lung cancer.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 1854985-74-2
• MW: 1305.06
• Formula: C₆₂H₄₆F₆N₈O₁₈
• SMILES: OC(/C=C\C(O)=O)=O.[H][C@@]12[C@@H](C(NC3=C4)=NC3=CC=C4C(F)(F)F)[C@]1([H])C5=CC(OC6=C7C(NC=C6)=NC(CC7)=O)=CC=C5O2.OC(/C=C\C(O)=O)=O.[H][C@@]89[C@@H](C(NC%10=C%11)=NC%10=CC=C%11C(F)(F)F)[C@]8([H])C%12=CC(OC%13=C%14C(NC=C%13)=NC(CC%14)=O)=CC=C%12O9.OC(/C=C\C(O)=O)=O
• Target: Raf,EGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

135395339