Lifirafenib HCl

SKU: orb1739495

Description

Lifirafenib (BGB-283) is a novel RAF kinase and EGFR inhibitor that selectively targets cells with B-RAFV600E and EGFR alterations. It demonstrates potent antitumor activity in vitro by inhibiting ERK phosphorylation and proliferation, and in vivo by causing tumor regression in colorectal cancer xenograft models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 2025320-97-0
• MW: 513.9012
• Formula: C₂₆H₁₉ClF₃N₃O₃
• SMILES: Cl.[H][C@]12Oc3ccc(OC4=C5CCC(=O)N=C5NC=C4)cc3[C@@]1([H])[C@@H]2c1nc2ccc(cc2[nH]1)C(F)(F)F
• Target: Endogenous Metabolite,Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

171360799