Licoisoflavone B

SKU: orb1684462

Description

Licoisoflavone B is a bioactive isoflavonoid isolated from Glycyrrhiza uralensis. It acts as an inhibitor of the human cytochrome P450 enzymes CYP2C8 and CYP2C9 and exhibits antioxidant activity by inhibiting lipid peroxidation. This compound is a useful research tool for studying drug metabolism, enzyme inhibition, and oxidative stress in vitro.

Key Properties

• CAS Number: 66056-30-2
• MW: 352.34
• Purity: 99.79% (May vary between batches)
• Formula: C₂₀H₁₆O₆
• SMILES: O=C1C(=COC=2C=C(O)C=C(O)C12)C=3C=CC=4OC(C=CC4C3O)(C)C
• Target: Others
• Solubility: DMSO:40 mg/mL (113.53 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.84 mM)

Bioactivity

• In Vitro:
  We present the results of an in vitro investigation of the inhibitory effects of licoisoflavone A and Licoisoflavone B and sophoraisoflavone A isolated from Sophra mooracroftiana BETH ex BAKER on copper-induced protein oxidative modification of mice brain homogenate in vitro. Although inhibitory effect of sophoraisoflavone A was stronger than those of licoisoflavone A and Licoisoflavone B, genistein as a related isoflavone, and mannitol as a hydroxy radical scavenger, inhibitory effects of licoisoflavone A and Licoisoflavone B were weaker than those of genistein and mannitol

Storage & Handling

• Storage: keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Licoisoflavone B, Antifection

Compound Identifiers

PubChem CID

5481234

Josef L Ranner 1, Georg Stabl 2 3, Cindy Martyniak 1, Michael Paries 3, Andrea Spaccasassi 1 4, Caroline Gutjahr 2 3, Timo D Stark 1, Corinna Dawid Comprehensive Quantification of (Poly)phenols in Lotus japonicus with and without Arbuscular Mycorrhizal Symbiosis J Agric Food Chem, (2025)

PubMed: 40418640