LICOCHALCONEC

SKU: orb1222694

Description

Licochalcone C is an inhibitor of lipopolysaccharide-interferon-γ inflammation. It acts by improving antioxidant conditions and regulating inducible nitric oxide synthase expression. It acts as an inhibitor of recombinant human PTP1B assessed as hydrolysis of p-nitrophenyl phosphate.

Key Properties

• CAS Number: 144506-14-9
• MW: 338.39
• Purity: >98% (HPLC)
• Formula: C₂₁H₂₂O₄
• SMILES: COc1c(\C=C\C(=O)c2ccc(O)cc2)ccc(O)c1CC=C(C)C
• Target: Antioxidant
• Solubility: In Vitro: DMSO : 33.33 mg/mL (98.49 mM)

Bioactivity

• In Vitro:
  Licochalcone C could inhibit α- glucosidase, with IC50s of <100 nM and 92.43 μM for α- glucosidase and PTP1B, respectively. It is also indicated that Licochalcone C induces T24 cell apoptosis in a concentration dependent manner. Licochalcone C treatment reduces the levels of the anti apoptotic mRNAs (Bcl-2, Bcl-w and Bcl-XL) and increases expression of the pro-apoptotic mRNAs (Bax and Bim). The Bcl-2 family inhibitor (ABT-737) reduces apoptosis induced by licochalcone C in T24 cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Licochalcone C | Licochalcone-C

Quick Database Links

Gene Symbol

Antioxidant