Liarozole

SKU: orb1309484

Description

Liarozole

Research Area

Metabolism Research

Key Properties

• CAS Number: 115575-11-6
• MW: 308.76
• Purity: 99.38% (May vary between batches)
• Formula: C₁₇H₁₃ClN₄
• SMILES: Clc1cccc(c1)C(c1ccc2nc[nH]c2c1)n1ccnc1
• Target: Retinoid Receptor,Cytochromes P450
• Solubility: DMSO:55 mg/mL (178.13 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.48 mM)

Bioactivity

• Target IC50:
  CYP26:7 μM (IC50)
• In Vitro:
  Liarozole inhibits 17a-hydroxylase activity in bovine adrenal microsomes (IC50=0.15 μM) . Liarozole has modest inhibitory activity on cholesterol synthesis in human hepatoma cells(IC50=5 μM).Liarozole inhibits the metabolism of retinoic acid to more polar metabolites in hamster liver microsomes (IC50=2.2 μM), rat liver homogenate (IC50=0.14 μM), dunning prostate cancer homogenate (IC50=0.26 μM) and MCF-7 human breast cancer cells (almost complete block at 10μM) .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ovariectomized, inhibit, Liarozole, Mesenchymal, Inhibitor, MCF-7, Imidazole, Hydroxylation, Cytochrome P450, CYPs, CYP450, Retinoic acid receptors, RetinoidReceptor, Retinoid X receptors, Retinoid Receptor, SCID, R-75251 Dihydrochloride, R75251, R-75251, R75251 dihydrochloride, R75251 Dihydrochloride, R 75251, R 75251 Dihydrochloride, RAR/RXR

Compound Identifiers

PubChem CID

60652