LGF308

SKU: orb3210386

Description

LGF308 is a PROTAC degrader targeting BRD4, exhibiting selective cytotoxicity against cancer cells compared to normal cells. It facilitates the formation of a ternary complex between BRD4 and DCAF11, leading to BRD4 degradation. LGF308 induces apoptosis in tumor cells by upregulating apoptosis-related proteins and inhibits proliferation and migration in breast cancer and triple-negative breast cancer cell lines. LGF308 is applicable for breast cancer research.

Key Properties

• CAS Number: 3061406-69-4
• MW: 732.27
• Formula: C₃₅H₃₄ClN₇O₅S₂
• SMILES: CC=1C2=C(N3C([C@H](CC(NCCCCCCN4C(=O)C(=CC5=CC(N(=O)=O)=CC=C5)SC4=O)=O)N=C2C6=CC=C(Cl)C=C6)=NN=C3C)SC1C
• Target: PROTACs,Epigenetic Reader Domain

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PROTACs,Epigenetic Reader Domain