LGE-899

SKU: orb1306553

Description

LGE-899 (M48) is the primary active metabolite of the hedgehog pathway inhibitor Sonidegib, characterized by a significantly extended Tmax of approximately 60 hours. This metabolite is a valuable research tool for investigating the pharmacokinetics and sustained pharmacodynamic effects of Sonidegib in both in vitro and in vivo experimental models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1221722-10-6
• MW: 296.24
• Purity: 99.93% (May vary between batches)
• Formula: C₁₅H₁₁F₃O₃
• SMILES: Cc1c(cccc1-c1ccc(OC(F)(F)F)cc1)C(O)=O
• Target: Drug Metabolite
• Solubility: DMSO:10 mg/mL (33.76 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DrugMetabolite, Drug Metabolite, circulating metabolite of Sonidegib, inhibit, Inhibitor, LGE 899, LGE899, LGE-899, hedgehog pathway inhibitor, Sonidegib metabolite M48, Sonidegib metabolite M-48, Sonidegib metabolite M 48

Compound Identifiers

PubChem CID

53228253