LG100268

SKU: orb1706002

Description

LG100268 is a potent, selective, and orally active retinoid X receptor (RXR) agonist with nanomolar activity against RXR-α, -β, and -γ. It has been used in research to study adipocyte differentiation, sexual differentiation in fish models, and modulation of PD-L1 in breast cancer cell lines, demonstrating utility in metabolic and oncology studies.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research

Key Properties

• CAS Number: 153559-76-3
• MW: 363.49
• Purity: 99.83% (May vary between batches)
• Formula: C₂₄H₂₉NO₂
• SMILES: O=C(O)C1=CN=C(C=C1)C2(C=3C=C4C(=CC3C)C(C)(C)CCC4(C)C)CC2
• Target: Autophagy,Retinoid Receptor,PD-1/PD-L1
• Solubility: DMSO:4 mg/mL (11 mM)

Bioactivity

• In Vivo:
  Methods: To prevent invasive breast cancer, MMTV-erbB2 mice were treated chronically with vehicle, LG100268 (10 mg/kg), or LG100268 (100 mg/kg) by gavage starting at 3 months of age. For pre-invasive lesion studies, mice were treated with vehicle or LG100268 (100 mg/kg) by daily gavage for 4 months. Results: Chronic LG100268 treatment significantly prevented the development of invasive breast tumors. The median time to tumor development (age) was delayed from 217 days in the vehicle group to 357 days in the low-dose group. In the high-dose group, only 2 of 20 mice developed tumors after 430 days of treatment.
• In Vitro:
  Methods: RAW264.7 cells were treated with LG100268 (100 nM-1 μM, 24 hours) and protein level changes were detected by WB. Results: LG100268 can downregulate CSF3 in RAW264.7 cells and reduce CXCL2 and IL-1β mRNA expression by 2.5 times.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LG 100268, LG100268, LG-100268, LGD1268, LGD 1268, LG268, ALRT 268

Compound Identifiers

PubChem CID

3922