LG-100064

SKU: orb1309485

Description

LG-100064 is a retinoid X receptor (RXR) agonist with EC50 values of 330 nM for RXRα, 200 nM for RXRβ, and 260 nM for RXRγ. It is used in research on nuclear receptor signaling, metabolic diseases, and cancer, facilitating in vitro transcriptional assays and in vivo studies in diabetes and atherosclerosis models.

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 153559-46-7
• MW: 350.45
• Purity: 98.65%
• Formula: C₂₃H₂₆O₃
• SMILES: Cc1cc2c(cc1C(=O)c1ccc(cc1)C(O)=O)C(C)(C)CCC2(C)C
• Target: Autophagy,Retinoid Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.71 mM);DMSO:49 mg/mL (139.82 mM)

Bioactivity

• Target IC50:
  RXRβ:200 nM (EC50)|RXRα:330 nM (EC50)|RXRγ:260 nM (EC50)
• In Vitro:
  LG-100064 shows no effect on RARα/β/γ (EC50, >10000 nM).LG-100064 (3-Methyl-TTNCB) is a retinoid-X-receptor (RXR) agonist, with EC50s of 330 nM, 200 nM, and 260 nM for RXRα, RXRβ and RXRγ.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Autophagy, LG 100064, LG100064, LG-100064, Inhibitor, inhibit, RAR/RXR, Retinoid X receptors, RetinoidReceptor, Retinoic acid receptors, Retinoid Receptor, RXRα, RXRβ, RXRγ

Compound Identifiers

PubChem CID

9810431