Levalbuterol tartrate

SKU: orb1300015

Description

Levalbuterol tartrate is the pharmacologically active (R)-enantiomer of the bronchodilator salbutamol, functioning as a short-acting β2-adrenergic agonist. It is widely used in research to study airway smooth muscle relaxation and β2-AR signaling in both in vitro cellular assays and in vivo models of respiratory function.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 661464-94-4
• MW: 389.39
• Purity: 99.98% (May vary between batches)
• Formula: C₁₇H₂₇NO₉
• SMILES: O[C@H]([C@@H](O)C(O)=O)C(O)=O.CC(C)(C)NC[C@H](O)c1ccc(O)c(CO)c1.CC(C)(C)NC[C@H](O)c1ccc(O)c(CO)c1
• Target: Adrenergic Receptor
• Solubility: DMSO:27.5 mg/mL (70.62 mM)

Bioactivity

• In Vivo:
  METHODS: In a randomized, double-blind, placebo-controlled, three-way crossover study, 30 stable asthmatic patients received a single dose of 100 mcg of levalbuterol tartrate, 200 mcg of salbutamol, or placebo using a pMDI. Forced expiratory volume in 1 second (FEV(1)) and forced vital capacity (FVC) were measured at baseline and within 6 hours after dosing. RESULTS Levalbuterol tartrate and salbutamol produced a significantly superior bronchodilator response to placebo. Both drugs demonstrated equivalent time-dependent bronchodilator responses as measured by the area under the curve for percent change in FEV(1) and FVC over 6 hours. The onset of action, mean maximum bronchodilator response, and duration of bronchodilator response were similar for levalbuterol tartrate and salbutamol.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Beta Receptor, Adrenergic Receptor, AdrenergicReceptor, inhibit, Inhibitor, Levosalbutamol, Levosalbutamol tartrate, Levosalbutamol Tartrate, Levalbuterol Tartrate, Levalbuterol tartrate, Levalbuterol, β2-adrenergic receptor

Compound Identifiers

PubChem CID

10349032