[Leu5]-Enkephalin

SKU: orb1220492

Description

[Leu5]-Enkephalin is an endogenous neuropeptide involved in nociception and an agonist of δ-opioid and μ-opioid receptors (Kis = 4.0 and 3.4 nM respectively).

Research Area

Cell Biology

Key Properties

• CAS Number: 58822-25-6
• MW: 555.62
• Purity: >98% (HPLC)
• Formula: C₂₈H₃₇N₅O₇
• SMILES: CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(O)=O
• Target: Opioid Receptor
• Solubility: DMSO:150 mg/mL (269.97 mM)

Bioactivity

• In Vitro:
  Enkephalins (met-, leu-enkephalin, and enkephalin 8) and dynorphins are two classes of opioid peptides found in the spinal dorsal horn. Mu, delta, and kappa are three major subtypes of opioid receptors. Enkephalins are putative endogenous ligands for delta opioid receptors, and dynorphins are endogenous ligands for the kappa opioid receptors. Three receptor types resembling the vertebrate δ- and κ-type opioid receptors have been characterized pharmacologically in nervous tissues (e. g. Ki=18.9 nM for Leu-enkephalin) and localized by autoradiography at CHH terminals in the SG of C. maenas. Leucine-enkephalin is a pentapeptides with morphine like properties, naturally present in mammalian brain.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Leu-enkephalin | Leucine enkephalin | Leucyl-enkephalin

Quick Database Links

Gene Symbol

Opioid Receptor