Leu-PEG1-Dasa

SKU: orb3177183

Description

Leu-PEG1-Dasa is a potent BCR-ABL PROTAC degrader with a DC50 of 0.48 nM. It employs a single amino acid as an E3 ligase ligand, categorizing it as a "mini-PROTAC," and operates via the N-degron pathway. Leu-PEG1-Dasa exhibits strong antiproliferative activity against K562 cells and is applicable in chronic myelogenous leukemia (CML) research.

Research Area

Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 3037776-72-7
• MW: 716.3
• Formula: C₃₃H₄₆ClN₉O₅S
• SMILES: N(C1=CC(N2CCN(CCOC(CCOCCNC([C@H](CC(C)C)N)=O)=O)CC2)=NC(C)=N1)C=3SC(C(NC4=C(C)C=CC=C4Cl)=O)=CN3
• Target: Bcr-Abl,PROTACs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Bcr-Abl,PROTACs