Leteprinim

SKU: orb1304367

Description

Leteprinim

Research Area

Immunology & Inflammation, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 138117-50-7
• MW: 327.29
• Purity: 99.08%
• Formula: C₁₅H₁₃N₅O₄
• SMILES: C(CC(NC1=CC=C(C(O)=O)C=C1)=O)N2C3=C(C(=O)N=CN3)N=C2
• Target: Reactive Oxygen Species,Others,ROS
• Solubility: DMSO:12.5 mg/mL (38.19 mM)

Bioactivity

• In Vivo:
  Leteprinim (60 mg/kg/day; i.p., for 7 days, starting from 20 min before the kainate injection) did not modify the seizures caused by kainate but, like diazepam, it decreased kainate-induced mortality, the reduction of GAD activity, and the loss of hippocampal neurons in rats.
• In Vitro:
  Leteprinim stimulates the outgrowth of neurites from PC12 cells and neurons, stimulates the synthesis and/or release of neurotrophic factors from astrocytes, enhances nerve fibre regeneration in vivo, and enhances memory in animals and humans. Leteprinim also protects against glutamate neurotoxicity in vitro and in vivo, which has led to successful tests of Leteprinim in animal models of acute central nervous system injury.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Leteprinim, AIT 082 acid, AIT082 acid, AIT-082 acid

Compound Identifiers

PubChem CID

135409548