Lestaurtinib

SKU: orb1707082

Description

Lestaurtinib

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 111358-88-4
• MW: 439.46
• Purity: 99.17%
• Formula: C₂₆H₂₁N₃O₄
• SMILES: C[C@]12N3C=4C=5N(C=6C(C5C7=C(C4C=8C3=CC=CC8)CNC7=O)=CC=CC6)[C@](O1)(C[C@@]2(CO)O)[H]
• Target: JAK,FLT,Apoptosis,STAT,Trk receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.55 mM);DMSO:40 mg/mL (91.02 mM)

Bioactivity

• Target IC50:
  FLT3:3 nM|TrkA:25 nM|JAK2:0.9 nM
• In Vivo:
  METHODS: Lestaurtinib (20 mg/kg; subcutaneous injection; twice daily from Monday to Friday and once daily on Saturday and Sunday; for 3 weeks) was administered to four-week-old athymic nude mice (SY5Y-TrkB xenograft model) to evaluate its therapeutic effect in a preclinical neuroblastoma model. Results: Lestaurtinib significantly slowe the growth of SY5Y-TrkB xenografts.
• In Vitro:
  METHODS: Cells were treated with different concentration of Lestaurtinib (0.5 μM and 4.0 μM) and cell viability was assessed using PrestoBlue at different time points (0, 24, 48, and 72 hours) by measurin the fluorescence intensity to evaluate cell proliferation. Results: Lestaurtinib demonstrated good Proliferative inhibitory activity agains the KMH2, CAL62, and THJ-21T cell line.

Storage & Handling

• Storage: store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

KT5555, KT-5555, KT 5555, JAK2, Lestaurtinib, FLT3, Apoptosis, CEP 701, CEP701, CEP-701, Trk receptor, TrkA, Trkreceptor

Compound Identifiers

PubChem CID

126565