Leriglitazone hydrochloride

• Catalog Number: orb1983413
• Category: Small Molecules
• Description: Leriglitazone (Hydroxypioglitazone) hydrochloride, a pioglitazone metabolite, acts as a PPARγ agonist, effectively stabilizing the PPARγ activation function-2 (AF-2) co-activator binding surface to enhance co-activator binding, which results in a modest improvement in transcriptional efficacy. It binds to the PPARγ C-terminal ligand-binding domain (LBD) with a dissociation constant (K i) of 1.2 μM and demonstrates transcriptional efficacy with an effective concentration (EC 50) of 680 nM [1].
• Purity: 98.00%
• MW: 408.90
• Biological Activity: Leriglitazone (Hydroxypioglitazone) hydrochloride, a pioglitazone metabolite, acts as a PPARγ agonist, effectively stabilizing the PPARγ activation function-2 (AF-2) co-activator binding surface to enhance co-activator binding, which results in a modest improvement in transcriptional efficacy. It binds to the PPARγ C-terminal ligand-binding domain (LBD) with a dissociation constant (K i) of 1.2 μM and demonstrates transcriptional efficacy with an effective concentration (EC 50) of 680 nM [1].
• CAS Number: 146062-46-6
• Formula: C₁₉H₂₁ClN₂O₄S
• SMILES: Cl.CC(O)c1ccc(CCOc2ccc(CC3SC(=O)NC3=O)cc2)nc1
• Storage: -20°C
• Note: For research use only