LEQ506

SKU: orb1309487

Description

LEQ506 is a potent and selective small molecule inhibitor of Smoothened (Smo), demonstrating IC50 values of 2 nM for human and 4 nM for mouse Smo. It is a valuable research tool for investigating Hedgehog signaling pathway biology in both in vitro cellular assays and in vivo preclinical models.

Research Area

Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1204975-42-7
• MW: 432.56
• Purity: 99.76% (May vary between batches)
• Formula: C₂₅H₃₂N₆O
• SMILES: C[C@@H]1CN(CCN1c1cnc(cn1)C(C)(C)O)c1nnc(Cc2ccccc2)c(C)c1C
• Target: Smo
• Solubility: DMSO:100 mg/mL (231.18 mM)

Bioactivity

• Target IC50:
  Smo (human):2 nM |Smo (mouse):4 nM
• In Vitro:
  LEQ506 consistently decreases Gli1 mRNA by about 70 to 80%. LEQ506 shows a tendency to preferentially inhibit Gli1 rather than Ptch1 mRNA. LEQ506 (at 1%) is also an efficacious compound with an inhibition of 80 to 90% for Gli1 and 60 to 70% for Ptch1. LEQ506 inhibits Hedgehog signaling in a human cell line (HEPM) as measured by the amount of Gli mRNA with an IC50 ~6-fold lower than that of Compound 2.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, mSmo, mouse smo, NVP-LEQ 506, NVP-LEQ506, NVP-LEQ-506, hSmo, human smo, LEQ506, LEQ-506, LEQ 506, Smo, Smoothened

Compound Identifiers

PubChem CID

45100669