Leptomycin B

SKU: orb1308129

Description

Leptomycin B is a potent antifungal antibiotic and cell cycle blocker that covalently inactivates CRM1/exportin 1, inhibiting nuclear protein export. It is widely used in vitro and in vivo to study nucleocytoplasmic transport, cell cycle regulation, and cancer research.

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 87081-35-4
• MW: 540.73
• Purity: 99.71% (May vary between batches)
• Formula: C₃₃H₄₈O₆
• SMILES: CC\C(\C=C\[C@H]1OC(=O)C=C[C@@H]1C)=C\[C@H](C)C\C=C\C(\C)=C\[C@@H](C)C(=O)[C@@H](C)[C@H](O)[C@@H](C)C\C(C)=C\C(O)=O
• Target: Antifungal,CRM1,Antibiotic
• Solubility: DMSO:101 mg/mL (186.78 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (7.4 mM)

Storage & Handling

• Storage: store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Chromosomal Maintenance 1, CI 940, CI940, CI-940, CRM1/exportin 1, CRM1, Antibiotic, cancer, mutation, inhibit, KRAS, LMB, p53, NSCLC, nuclear export, EGFR, Exportin 1, EMT, Fungal, Inhibitor, Leptomycin B, XPO1, resistance

Compound Identifiers

PubChem CID

6436291