Leptomerine

SKU: orb1297303

Description

Leptomerine is an alkaloid isolated from Esenbeckia leiocarpa with demonstrated anticholinesterase activity. This property makes it a relevant small molecule for in vitro studies targeting acetylcholinesterase inhibition in Alzheimer's disease research.

Research Area

Neuroscience

Key Properties

• CAS Number: 22048-97-1
• MW: 201.26
• Purity: 99.96%
• Formula: C₁₃H₁₅NO
• SMILES: CN1C=2C(C(=O)C=C1CCC)=CC=CC2
• Target: Cholinesterase (ChE)
• Solubility: DMSO:9 mg/mL (44.72 mM)

Bioactivity

• Target IC50:
  AChE:2.5 mM
• In Vitro:
  Bioactivity-guided fractionation o the ethanol stems extract afforde the isolation of Six alkaloids: leiokinine A, Leptomerine, kokusaginine, skimmianine, maculine and flindersiamine. All isolated compounds were tested for acetyl cholinesterase inhibition, in vitro and displayed anticholinesterasic activity the alkaloid Leptomerine showe the highest activity IC50 = 2.5 mM), similar to that o the reference compound galanthamine IC50 = 1.7 mM).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Alzheimer, AChE, AChR, activity, acetyl, Anticholinesterasic, cholinesterase, Cholinesterase (ChE), Inhibitor, Leptomerine, inhibit

Compound Identifiers

PubChem CID

10856530