Leonurine hydrochloride

SKU: orb1303184

Description

Leonurine hydrochloride (SCM-198 hydrochloride) is a bioactive alkaloid isolated from Leonurus japonicus. It has demonstrated antitumor potential in research, with studies indicating activity in both in vitro cell-based assays and in vivo animal models of cancer.

Research Area

Cell Biology, Immunology & Inflammation

Key Properties

• CAS Number: 24735-18-0
• MW: 347.79
• Purity: 99.47%
• Formula: C₁₄H₂₂ClN₃O₅
• SMILES: Cl.COc1cc(cc(OC)c1O)C(=O)OCCCCNC=NN
• Target: TLR,Autophagy
• Solubility: DMSO:100 mg/mL (287.53 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (9.49 mM)

Bioactivity

• In Vivo:
  Leonurine hydrochloride can elevate the ET level and ET/NO ratio in rats with up-regulated ETA mRNA expression and induced abortions, but there is no change in ETB mRNA. Compared with the model group, Leonurine hydrochloride treatment markedly reduces the volume of bleeding and intrauterine residual, and markedly shortens the duration of bleeding. Leonurine hydrochloride also obviously reinforces the tension and frequency of uterine contractions .
• In Vitro:
  The treatment of Leonurine hydrochloride (10-50 μM) for 24 h increases apoptotic ratio from 4.9% to 11.5-61.3%, respectively. The inhibition effect of Leonurine hydrochloride on H292 cells is related to the generation of ROS and the loss of MMP. Leonurine hydrochloride can increase the phosphorylation level of p38 and reduce Akt phosphorylation. Furthermore, Leonurine hydrochloride treatment increases the expression levels of caspase-3, caspase-9 and Bax/Bcl-2. In RAW 264.7 cells and mouse bone marrow monocytes (BMMs), Leonurine hydrochloride suppresses RANKL-induced osteoclastogenesis and actin ring formation in a dose-dependent manner .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Autophagy, inhibit, Leonurine, Leonurine Hydrochloride, Leonurine hydrochloride, Inhibitor, SCM 198, SCM 198 Hydrochloride, SCM198, SCM-198, SCM-198 HCl, SCM198 Hydrochloride, SCM-198 hydrochloride, SCM-198 Hydrochloride, TLR

Compound Identifiers

PubChem CID

137699085