Lenalidomide-OH

SKU: orb1307403

Description

Lenalidomide-OH is a cereblon (CRBN)-binding derivative of lenalidomide, designed for use as a key ligand component in constructing PROTAC molecules. It enables targeted protein degradation and is widely utilized in both in vitro and in vivo research to study ubiquitin-proteasome pathways and therapeutic modalities.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1416990-08-3
• MW: 260.245
• Purity: 99.77% (May vary between batches)
• Formula: C₁₃H₁₂N₂O₄
• SMILES: O=C(C(N(CC1=C2C=CC(O)=C1)C2=O)CC3)NC3=O
• Target: Ligands for E3 Ligase,PROTAC Linker
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.68 mM);DMSO:11 mg/mL (42.27 mM)

Bioactivity

• In Vitro:
  Lenalidomide-OH can be linked to a protein ligand via a linker to form PROTACs, which induce the ubiquitination-mediated degradation of cancer-promoting proteins .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

E3 ligase-recruiting Moiety, Cereblon, Ligands for E3 Ligase, LigandforE3Ligase, Ligand for E3 Ligase, inhibit, Inhibitor, Lenalidomide OH, LenalidomideOH, Lenalidomide-OH

Compound Identifiers

PubChem CID

71517902