Lenalidomide-CO-C7-NH2

SKU: orb3210613

Description

Lenalidomide-CO-C7-NH2 acts as an intermediate in the synthesis of a CRBN-dependent BET PROTAC degrader, known as PROTACBET Degrader-16. This compound is formed by the conjugation of the E3 ubiquitin ligase ligand Lenalidomide and the PROTA Clinker. It facilitates the selective degradation of the oncogenic protein BRD4, effectively suppressing cancer cell proliferation, inducing cell cycle arrest, and promoting apoptosis (apoptosis). This leads to significant antitumor activity in xenograft models. Lenalidomide-CO-C7-NH2 serves as a crucial molecular tool in studying acute myeloid leukemia.

Key Properties

• CAS Number: 1957236-16-6
• MW: 400.47
• Formula: C₂₁H₂₈N₄O₄
• SMILES: O=C1NC(=O)C(N2C(=O)C=3C=CC=C(NC(=O)CCCCCCCN)C3C2)CC1
• Target: E3 Ligase Ligand-Linker Conjugates

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

E3 Ligase Ligand-Linker Conjugates