Lenalidomide-Br

SKU: orb1307404

Description

Lenalidomide-Br is a cereblon (CRBN)-binding ligand derivative used to construct PROTAC molecules, such as the STAT3 degrader SD-36. It serves as a key component in bifunctional degraders for targeted protein elimination, with applications in oncology research and demonstrated utility in both cellular and in vivo studies.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2093387-36-9
• MW: 323.14
• Purity: 98.37%
• Formula: C₁₃H₁₁BrN₂O₃
• SMILES: O=C1N(CC=2C1=CC=CC2Br)C3C(=O)NC(=O)CC3
• Target: Ligands for E3 Ligase,PROTAC Linker
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.09 mM);DMSO:30 mg/mL (92.84 mM)

Bioactivity

• In Vivo:
  Lenalidomide-Br can form a PROTAC by coupling with a protein's ligand. PROTAC acts as an inducer of ubiquitin-mediated degradation of oncogenic proteins .
• In Vitro:
  Lenalidomide-Br can be conjugated to a protein ligand via a linker, forming PROTACs that induce the ubiquitination-mediated degradation of oncogenic proteins.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Lenalidomide Br, LenalidomideBr, Lenalidomide-Br, E3 ligase-recruiting Moiety, inhibit, LigandforE3Ligase, Ligand for E3 Ligase, Ligands for E3 Ligase, ligase, Inhibitor, cereblon, Cereblon, analog, ubiquitin, recruitment, protein, PROTAC

Compound Identifiers

PubChem CID

131986901