Lenaldekar

SKU: orb1305485

Description

Lenaldekar (LDK) is a small molecule inhibitor that suppresses T-cell proliferation and the development of autoimmune encephalomyelitis. It functions by inducing dephosphorylation of PI3K/AKT/mTOR pathway components and arresting sensitive cells in late mitosis, making it a useful research tool for immunology and oncology studies both in vitro and in vivo.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 418800-15-4
• MW: 286.33
• Purity: 99.25% (May vary between batches)
• Formula: C₁₈H₁₄N₄
• SMILES: N(\N=C\C1=CNC2=CC=CC=C12)C1=CC=CC2=CC=CN=C12
• Target: IGF-1R,Apoptosis,S6 Kinase,Akt
• Solubility: DMSO:55 mg/mL (192.09 mM)

Bioactivity

• In Vivo:
  Relapsing-remitting experimental autoimmune encephalomyelitis was induced through active immunization of SJL/J mice with a myelin proteolipid protein peptide. The therapeutic efficacy of Lenaldekar treatment was evaluated via daily clinical score, cross-sectional ex vivo diffusion basis spectrum imaging examination and histological analysis. Lenaldekar greatly reduced relapse severity and protected white matter integrity in these experimental autoimmune encephalomyelitis mice. Diffusion basis spectrum imaging-derived axial diffusivity, radial diffusivity and restricted diffusion tensor fraction accurately reflected axonal injury, myelin integrity and inflammation-associated cellularity change, respectively.
• In Vitro:
  Lenaldekar could inhibit myelin specific T cell responses through the insulin-like growth factor-1 receptor (IGF-1R) pathway. Alteration of this pathway led to marked reduction in T cell proliferation and expansion. Blocking this pathway could account for the observed decreases in clinical signs and inflammatory demyelinating disease, which was accompanied by axonal preservation.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

S6Kinase, S6 Kinase, P-Akt (T308), P-Akt (S473), LDK, Lenaldekar, IGF1R, IGF-1R

Compound Identifiers

PubChem CID

135470799