LEI110

SKU: orb1297896

Description

LEI110 is a potent and selective pan-inhibitor of the HRASLS thiol hydrolase family, including PLA2G16 (Ki=20 nM), HRASLS2, RARRES3, and iNAT. This small molecule is a valuable research tool for studying lipid metabolism and signaling in both cellular and animal models of metabolic disorders and cancer.

Research Area

Metabolism Research

Key Properties

• CAS Number: 2313525-90-3
• MW: 456.46
• Purity: 98.80% (May vary between batches)
• Formula: C₂₅H₂₃F₃N₂O₃
• SMILES: FC(F)(F)c1ccc(Oc2ccc(CCNC(=O)C(=O)CCCc3ccccc3)cc2)nc1
• Target: Phospholipase
• Solubility: 10% DMSO+90% Corn Oil:2.5 mg/mL (5.48 mM);DMSO:50 mg/mL (109.54 mM)

Bioactivity

• Target IC50:
  PLA2G16:20 nM(Ki)
• In Vitro:
  LEI110 reduces cellular arachidonic acid levels in PLA2G16-overexpressing U2OS cells and oleic acid-induced steatosis in human HepG2 cells.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, lipolysis, Inhibitor, HepG2 cells, LEI 110, LEI110, LEI-110, thiol hydrolases, PLA2G16, Phospholipase

Compound Identifiers

PubChem CID

156013201