Lefamulin acetate

SKU: orb1309488

Description

Lefamulin acetate

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1350636-82-6
• MW: 567.78
• Purity: 99.93% (May vary between batches)
• Formula: C₃₀H₄₉NO₇S
• SMILES: CC(O)=O.[H][C@@]12C(=O)CC[C@]11CC[C@@H](C)[C@@]2(C)[C@@H](C[C@@](C)(C=C)[C@@H](O)[C@@H]1C)OC(=O)CS[C@@H]1CC[C@@H](N)C[C@H]1O
• Target: ribosome,Antibacterial,Antibiotic
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (5.81 mM);DMSO:99 mg/mL (174.36 mM)

Bioactivity

• In Vitro:
  Lefamulin has activity against gram-negative organisms, including Haemophilus influenza (MIC50=1 μg/ml; MIC90=0.12 μg/ml) and Moraxella cotarrhali (MIC50=2 μg/ml; MIC90=0.25 μg/ml).Lefamulin acetate (BC-3781 acetate) has activity against the resistant gram-postive organisms, including taphylococcus aureus (MRSA) (MIC50=0.12 μg/ml; MIC90=0.25 μg/ml); β-Hemolytic strepococcus (MIC50=0.03 μg/ml; MIC90=0.03 μg/ml); Viridans group Streptococcus (MIC50=0.12 μg/ml; MIC90=0.5 μg/ml), Enterocossus faecium (MIC50=0.12 μg/ml; MIC90=4 μg/ml), Streptococcus pneumonia (MIC50=0.12 μg/ml; MIC90 =0.25 μg/ml).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bacterial, Antibiotic, BC 3781, BC 3781 Acetate, BC3781, BC-3781, BC3781 Acetate, BC-3781 acetate, BC-3781 Acetate, 50S ribosome, Inhibitor, inhibit, Lefamulin, Lefamulin acetate, Lefamulin Acetate

Compound Identifiers

PubChem CID

86346053